abstract：:Of the six fatty acid elongase (Elovl) subtypes expressed in mammals, adult rat liver expresses four subtypes: Elovl-5 > Elovl-1 = Elovl-2 = Elovl-6. Overnight starvation and fish oil-enriched diets repressed hepatic elongase activity in livers of adult male rats. Diet-induced changes in elongase activity correlate wi...

journal_title：Journal of lipid research

authors： Wang Y,Botolin D,Christian B,Busik J,Xu J,Jump DB

更新日期：2005-04-01 00:00:00

abstract：:Serum triglyceride (TG) levels are increased in extremely obese individuals, indicating abnormalities in lipid metabolism and insulin resistance. We carried out a genome scan for serum TG in 320 nuclear families segregating extreme obesity and normal weight. Three hundred eighty-two Marshfield microsatellite markers (...

journal_title：Journal of lipid research

authors： Li WD,Dong C,Li D,Garrigan C,Price RA

更新日期：2005-03-01 00:00:00

abstract：:HDL-associated paraoxonase type 1 (PON1) can protect LDL and HDL against oxidative modification in vitro and therefore may protect against cardiovascular disease. We investigated the effects of PON1 levels, activity, and genetic variation on high density lipoprotein-cholesterol (HDL-C) levels, circulating oxidized LDL...

journal_title：Journal of lipid research

authors： van Himbergen TM,Roest M,de Graaf J,Jansen EH,Hattori H,Kastelein JJ,Voorbij HA,Stalenhoef AF,van Tits LJ

更新日期：2005-03-01 00:00:00

abstract：:Atherosclerosis is a chronic inflammatory response characterized by the accumulation of cells of innate and acquired immune systems within the intima of the arterial wall. Macrophages are the predominant participant in innate immune responses in atherosclerosis. Protein receptors expressed by macrophages and endotheli...

journal_title：Journal of lipid research

authors： Tobias P,Curtiss LK

更新日期：2005-03-01 00:00:00

abstract：:N-arachidonylethanolamine (AEA) accumulates during brain injury and postmortem. Because fatty acid amide hydrolase (FAAH) regulates brain AEA content, the purpose of this study was to determine its role in the postmortal accumulation of AEA using FAAH null mice. As expected, AEA content in immediately frozen brain tis...

journal_title：Journal of lipid research

authors： Patel S,Carrier EJ,Ho WS,Rademacher DJ,Cunningham S,Reddy DS,Falck JR,Cravatt BF,Hillard CJ

更新日期：2005-02-01 00:00:00

abstract：:The aim of this study was first to examine the relationships between adiponectin gene (Apm1) polymorphisms and anthropometric indices as well as plasma adiponectin and lipoprotein/lipid levels, and then to investigate whether the presence of visceral obesity or insulin resistance may modulate the impact of these polym...

journal_title：Journal of lipid research

authors： Berthier MT,Houde A,Côté M,Paradis AM,Mauriège P,Bergeron J,Gaudet D,Després JP,Vohl MC

更新日期：2005-02-01 00:00:00

abstract：:The CYP27A gene encodes a mitochondrial cytochrome P450 enzyme, sterol 27-hydroxylase, that is expressed in many different tissues and plays an important role in cholesterol and bile acid metabolism. In humans, CYP27A deficiency leads to cerebrotendinous xanthomatosis. To gain insight into the roles of CYP27A in the r...

journal_title：Journal of lipid research

authors： Dubrac S,Lear SR,Ananthanarayanan M,Balasubramaniyan N,Bollineni J,Shefer S,Hyogo H,Cohen DE,Blanche PJ,Krauss RM,Batta AK,Salen G,Suchy FJ,Maeda N,Erickson SK

更新日期：2005-01-01 00:00:00

abstract：:The resistin gene is expressed in adipocytes and encodes a protein proposed to link obesity and type 2 diabetes. Increased plasma FFA is associated with insulin resistance. We examined the effect of separate FFAs on the expression of resistin mRNA in cultured murine 3T3-L1 adipocytes. The FFAs tested did not increase ...

journal_title：Journal of lipid research

authors： Haugen F,Zahid N,Dalen KT,Hollung K,Nebb HI,Drevon CA

更新日期：2005-01-01 00:00:00

abstract：:Apolipoprotein A-I (apoA-I) induces the translocation of newly synthesized cholesterol as well as caveolin-1 to the cytosolic lipid-protein particle (CLPP) fraction in astrocytes before its appearance in high density lipoprotein generated in the medium (Ito, J., Y. Nagayasu, K. Kato, R. Sato, and S. Yokoyama. 2002. Ap...

journal_title：Journal of lipid research

authors： Ito J,Li H,Nagayasu Y,Kheirollah A,Yokoyama S

更新日期：2004-12-01 00:00:00

abstract：:The percentage of saturated cholesteryl esters (CEs) synthesized by human LCAT is several times higher than expected from the sn-2 acyl composition of plasma phosphatidylcholine (PC), whereas the synthesis of 20:4 CE and 22:6 CE is much lower than expected. To explain these discrepancies, we proposed that LCAT transfe...

journal_title：Journal of lipid research

authors： Subbaiah PV,Sowa JM,Davidson MH

更新日期：2004-12-01 00:00:00

abstract：:A new sample preparation method coupled to GC-MS analysis was developed and validated for quantification of sulfate esters of pregnenolone (PREG-S) and dehydroepiandrosterone (DHEA-S) in rat brain. Using a solid-phase extraction recycling protocol, the results show that little or no PREG-S and DHEA-S (<1 pmol/g) is pr...

journal_title：Journal of lipid research

authors： Liere P,Pianos A,Eychenne B,Cambourg A,Liu S,Griffiths W,Schumacher M,Sjövall J,Baulieu EE

更新日期：2004-12-01 00:00:00

abstract：:Human endothelial lipase (EL), a member of the triglyceride lipase gene family, has five potential N-linked glycosylation sites, two of which are conserved in both lipoprotein lipase and hepatic lipase. Reduction in molecular mass of EL after treatment with glycosidases and after treatment of EL-expressing cells with ...

journal_title：Journal of lipid research

authors： Miller GC,Long CJ,Bojilova ED,Marchadier D,Badellino KO,Blanchard N,Fuki IV,Glick JM,Rader DJ

更新日期：2004-11-01 00:00:00

abstract：:Scavenger receptor class B type I (SR-BI) has been identified as a functional HDL binding protein that can mediate the selective uptake of cholesteryl ester (CE) from HDL. To quantify the in vivo role of SR-BI in the process of selective uptake, HDL was labeled with cholesteryl ether ([(3)H] CEt-HDL) and (125)I-tyrami...

journal_title：Journal of lipid research

authors： Out R,Hoekstra M,Spijkers JA,Kruijt JK,van Eck M,Bos IS,Twisk J,Van Berkel TJ

更新日期：2004-11-01 00:00:00

abstract：:The increased generation of reactive oxygen species that occurs in the condition of obesity may be responsible for oxidative injury to erythrocyte membranes, which could lead to a decrease in tissue oxygenation. Therefore, we have looked into the effects of obesity on both indexes of oxidative damage and physical-chem...

journal_title：Journal of lipid research

authors： Cazzola R,Rondanelli M,Russo-Volpe S,Ferrari E,Cestaro B

更新日期：2004-10-01 00:00:00

abstract：:Our goal was to further define the role of LPL gene polymorphisms in coronary heart disease (CHD) risk. We determined the frequencies of three LPL polymorphisms (D9N, N291S, and S447X) in 899 men from the Veterans Affairs HDL Intervention Trial (VA-HIT), a study that examined the potential benefits of increasing HDL w...

journal_title：Journal of lipid research

authors： Brousseau ME,Goldkamp AL,Collins D,Demissie S,Connolly AC,Cupples LA,Ordovas JM,Bloomfield HE,Robins SJ,Schaefer EJ

更新日期：2004-10-01 00:00:00

abstract：:Decreased HDL-cholesterol (HDL-C) and familial combined hyperlipidemia (FCHL) are the two most common familial dyslipidemias predisposing to premature coronary heart disease (CHD). These dyslipidemias share many phenotypic features, suggesting a partially overlapping molecular pathogenesis. This was supported by our p...

journal_title：Journal of lipid research

authors： Lilja HE,Suviolahti E,Soro-Paavonen A,Hiekkalinna T,Day A,Lange K,Sobel E,Taskinen MR,Peltonen L,Perola M,Pajukanta P

更新日期：2004-10-01 00:00:00

abstract：:Inositol lipid kinases have been studied extensively in both plant and animal systems. However, major limitations for in vitro studies of recombinant lipid kinases are the low specific activity and instability of the purified proteins. Our goal was to determine if cyclodextrins would provide an effective substrate del...

journal_title：Journal of lipid research

authors： Davis AJ,Perera IY,Boss WF

更新日期：2004-09-01 00:00:00

abstract：:Dietary n-3 PUFAs have been shown to attenuate T-cell-mediated inflammation. To investigate whether dietary n-3 PUFAs promote activation-induced cell death (AICD) in CD4+ T-cells induced in vitro to a polarized T-helper1 (Th1) phenotype, C57BL/6 mice were fed diets containing either 5% corn oil (CO; n-6 PUFA control) ...

journal_title：Journal of lipid research

authors： Switzer KC,Fan YY,Wang N,McMurray DN,Chapkin RS

更新日期：2004-08-01 00:00:00

abstract：:Unesterified cholesterol is an essential structural component of the plasma membrane of every cell. During evolution, this membrane came to play an additional, highly specialized role in the central nervous system (CNS) as the major architectural component of compact myelin. As a consequence, in the human the mean con...

journal_title：Journal of lipid research

authors： Dietschy JM,Turley SD

更新日期：2004-08-01 00:00:00

abstract：:Apolipoprotein A-IV (apoA-IV) has been postulated to be antiatherogenic. Transgenic APOA4/Apoe-/- mice are protected against atherosclerosis, with plasma apoA-IV displaying antioxidant activity in vitro. In humans, there is an inverse relationship between apoA-IV levels and risk of coronary heart disease (CHD). Furthe...

journal_title：Journal of lipid research

authors： Wong WM,Stephens JW,Acharya J,Hurel SJ,Humphries SE,Talmud PJ

更新日期：2004-08-01 00:00:00

abstract：:The 3-methyl-branched fatty acid phytanic acid is degraded by the peroxisomal alpha-oxidation route because the 3-methyl group blocks beta-oxidation. In adult Refsum disease (ARD), peroxisomal alpha-oxidation is defective, which is caused by mutations in the gene coding for phytanoyl-CoA hydroxylase in the majority of...

journal_title：Journal of lipid research

authors： Komen JC,Duran M,Wanders RJ

更新日期：2004-07-01 00:00:00

abstract：:Scavenger receptor class B type I (SR-BI) and ABCA1 are structurally dissimilar cell surface proteins that play key roles in HDL metabolism. SR-BI is a receptor that binds HDL with high affinity and mediates both the selective lipid uptake of cholesteryl esters from lipid-rich HDL to cells and the efflux of unesterifi...

journal_title：Journal of lipid research

authors： Nieland TJ,Chroni A,Fitzgerald ML,Maliga Z,Zannis VI,Kirchhausen T,Krieger M

更新日期：2004-07-01 00:00:00

abstract：:The ATP binding cassette (ABC) half-transporters ABCG5 and ABCG8 facilitate biliary and intestinal removal of neutral sterols. Here, we identify a binding site for the orphan nuclear receptor liver receptor homolog-1 (LRH-1) at nt 134-142 of the ABCG5/ABCG8 intergenic region necessary for the activity of both the ABCG...

journal_title：Journal of lipid research

authors： Freeman LA,Kennedy A,Wu J,Bark S,Remaley AT,Santamarina-Fojo S,Brewer HB Jr

更新日期：2004-07-01 00:00:00

abstract：:The inbred HcB19 mouse strain expresses a truncated form of thioredoxin interacting protein and is phenotypically characterized by fatty liver and elevated plasma triglycerides and VLDL. Recently, these mice have been proposed as an animal model for familial combined hyperlipidemia. The aim of the present study was id...

journal_title：Journal of lipid research

authors： Van Greevenbroek MM,Vermeulen VM,De Bruin TW

更新日期：2004-06-01 00:00:00

abstract：:We investigated the formation and pharmacology of prostaglandin E(3) (PGE(3)) derived from fish oil eicosapentaenoic acid (EPA) in human lung cancer A549 cells. Exposure of A549 cells to EPA resulted in the rapid formation and export of PGE(3.) The extracellular ratio of PGE(3) to PGE(2) increased from 0.08 in control...

journal_title：Journal of lipid research

authors： Yang P,Chan D,Felix E,Cartwright C,Menter DG,Madden T,Klein RD,Fischer SM,Newman RA

更新日期：2004-06-01 00:00:00

abstract：:Fatty liver is frequent in the apolipoprotein B (apoB)-defective genetic form of familial hypobetalipoproteinemia (FHBL), but interindividual variability in liver fat is large. To explain this, we assessed the roles of metabolic factors in 32 affected family members with apoB-defective FHBL and 33 related and unrelate...

journal_title：Journal of lipid research

authors： Tanoli T,Yue P,Yablonskiy D,Schonfeld G

更新日期：2004-05-01 00:00:00

abstract：:The use of lipoproteins has been suggested as a treatment for Gram-negative sepsis because they inhibit lipopolysaccharide (LPS)-mediated cytokine production. However, little is known about the neutralizing effects of lipoproteins on cytokine production by meningococcal LPS or whole Gram-negative bacteria. We assessed...

journal_title：Journal of lipid research

authors： Sprong T,Netea MG,van der Ley P,Verver-Jansen TJ,Jacobs LE,Stalenhoef A,van der Meer JW,van Deuren M

更新日期：2004-04-01 00:00:00

abstract：:The class B scavenger receptors SR-BI and CD36 exhibit a broad ligand binding specificity. SR-BI is well characterized as a HDL receptor that mediates selective cholesteryl ester uptake from HDL. CD36, a receptor for oxidized LDL, also binds HDL and mediates selective cholesteryl ester uptake, although much less effic...

journal_title：Journal of lipid research

authors： de Beer MC,Castellani LW,Cai L,Stromberg AJ,de Beer FC,van der Westhuyzen DR

更新日期：2004-04-01 00:00:00

abstract：:This study has examined the dimeric/oligomeric forms of scavenger receptor class B type I (SR-BI) and its alternatively spliced form, SR-BII, in a diverse group of cells and tissues: i.e., normal and hormonally altered tissues of mice and rats as well as tissues of transgenic animals and genetically altered steroidoge...

journal_title：Journal of lipid research

authors： Reaven E,Cortez Y,Leers-Sucheta S,Nomoto A,Azhar S

更新日期：2004-03-01 00:00:00

abstract：:Paraoxonase-1 (PON1) is known to be associated with high density lipoproteins. We optimized buffer conditions to obtain quantitative recovery of PON1 (arylesterase) activity and analyzed the distribution of PON1 in mice using a combination of size-exclusion chromatography and ultracentrifugation. Size-exclusion chroma...

journal_title：Journal of lipid research

authors： Connelly PW,Maguire GF,Draganov DI

更新日期：2004-03-01 00:00:00

abstract：:Sphingoglycolipids (SGLs) are cell membrane constituents. As the ceramide structure influences the biological properties of the SGL, we characterized by electrospray ionization tandem mass spectrometry the molecular species of ceramides present in SGL of mouse brain. We report here for the first time the presence in m...

journal_title：Journal of lipid research

authors： Colsch B,Afonso C,Popa I,Portoukalian J,Fournier F,Tabet JC,Baumann N

更新日期：2004-02-01 00:00:00

abstract：:Apolipoproteins, such as apolipoprotein A-I (apoA-I), can stimulate cholesterol efflux from cells expressing the ATP binding cassette transporter A1 (ABCA1). The nature of the molecular interaction between these cholesterol acceptors and ABCA1 is controversial, and models suggesting a direct protein-protein interactio...

journal_title：Journal of lipid research

authors： Fitzgerald ML,Morris AL,Chroni A,Mendez AJ,Zannis VI,Freeman MW

更新日期：2004-02-01 00:00:00

abstract：:Sphingolipid metabolites function as signaling molecules in mammalian cells, influencing cell proliferation, migration, and death. Recently, sphingolipid signaling has been implicated in the regulation of developmental processes in Drosophila melanogaster. However, biochemical analysis of endogenous Drosophila sphingo...

journal_title：Journal of lipid research

authors： Fyrst H,Herr DR,Harris GL,Saba JD

更新日期：2004-01-01 00:00:00

abstract：:It was reported previously that ceramide-1-phosphate (Cer-1-P) is mitogenic for fibroblasts (Gómez-Muñoz, A., P. A. Duffy, A. Martin, L. O'Brien, H-S. Byun, R. Bittman, and D. N. Brindley. 1995. Mol. Pharmacol. 47: 883-889; Gómez-Muñoz, A., L. M. Frago, L. Alvarez, and I. Varela-Nieto. 1997. Biochem. J. 325: 435-440)....

journal_title：Journal of lipid research

authors： Gómez-Muñoz A,Kong JY,Salh B,Steinbrecher UP

更新日期：2004-01-01 00:00:00

abstract：:The Delta6-desaturase catalyzes key steps in long-chain polyunsaturated fatty acid biosynthesis. Although the gene coding for this enzyme has been isolated in diverse animal species, the protein structure remains poorly characterized. In this work, rat Delta6-desaturase expressed in COS-7 cells was shown to localize i...

journal_title：Journal of lipid research

authors： Guillou H,D'Andrea S,Rioux V,Barnouin R,Dalaine S,Pedrono F,Jan S,Legrand P

更新日期：2004-01-01 00:00:00

abstract：:Visceral fat has been associated with multiple cardiovascular disease (CVD) risk factors. The aim of this study was to identify anthropometrical measures most closely associated with some well-known CVD risk factors. Because most Asians at risk have normal body mass index (BMI) according to Western standards, we studi...

journal_title：Journal of lipid research

authors： Jang Y,Kim OY,Ryu HJ,Kim JY,Song SH,Ordovas JM,Lee JH

更新日期：2003-12-01 00:00:00

abstract：:Mitochondrial sterol 27-hydroxylase (EC 1.14.13.15) is an important enzyme, not only in the formation of bile acids from cholesterol intermediates in the liver but also in the removal of cholesterol by side chain hydroxylation in extrahepatic tissues. The enzyme has been assayed by complicated methods using radiolabel...

journal_title：Journal of lipid research

authors： Ota Y,Eto TA,Tanaka S,Sueta H,Shiotsuki H,Maeda Y,Une M,Chijiiwa K

更新日期：2003-12-01 00:00:00

abstract：:The mRNA level for cytosolic NADP-dependent isocitrate dehydrogenase (IDH1) increases 2.3-fold, and enzyme activity of NADP-isocitrate dehydrogenase (IDH) 63%, in sterol-deprived HepG2 cells. The mRNA levels of the NADP- and NAD-dependent mitochondrial enzymes show limited or lack of regulation under the same conditio...

journal_title：Journal of lipid research

authors： Shechter I,Dai P,Huo L,Guan G

更新日期：2003-11-01 00:00:00

abstract：:Circulating triacylglycerol (TG) arises mainly from dietary fat. However, little is known about the entry of dietary fat into the major TG pool, very low-density lipoprotein (VLDL) TG. We used a novel method to study the specific incorporation of dietary fatty acids into postprandial VLDL TG in humans. Eight healthy v...

journal_title：Journal of lipid research

authors： Heath RB,Karpe F,Milne RW,Burdge GC,Wootton SA,Frayn KN

更新日期：2003-11-01 00:00:00

abstract：:Several different processes involved in the metabolic fate of docosahexaenoic acid (DHA, C22:6n-3) and its precursor in the biosynthesis route, C24:6n-3, were studied. In cultured skin fibroblasts, the oxidation rate of [1-14C] 24:6n-3 was 2.7 times higher than for [1-14C]22:6n-3, whereas [1-14C]22:6n-3 was incorporat...

journal_title：Journal of lipid research

authors： Ferdinandusse S,Denis S,Dacremont G,Wanders RJ

更新日期：2003-10-01 00:00:00